![]() ![]() Some of your patients may have had an allogeneic transplant which is truly the immune therapy of someone else’s immune system. The transplant doctor identifies potential matches and arranges donor testing.We’ve tried high-dose chemotherapy and I’m a stem cell transplanter, so the notion of using high-dose chemotherapy with stem cell rescue or what your patients will know as an auto transplant, has provided much benefit to the patients of mantle cell. If a donor is found to be a good match, a medical exam and blood tests are done to make sure the donor is in good health. It might seem unlikely, but it’s possible to find a good match with someone who is not a relative. If a match is not found within the family, the search starts for an unrelated donor through the Canadian Blood Services stem cell registry. The search for a donor starts with the recipient’s brothers and sisters because siblings have the greatest chance of being a match. Most matches are between close family members. But a transplant may still be done if the match is less than perfect. There are thousands of different combinations of possible HLA tissue types so it can be hard to find an exact match. A process called HLA (human leukocyte antigen) testing makes sure that the donor and recipient are closely matched. To improve the chance of a successful stem cell transplant, the donor’s stem cells need to match the recipient’s as closely as possible. Syngeneic transplants use stem cells from an identical twin. A mini-transplant is also called a reduced intensity transplant or non-myeloablative transplant. This may be useful for older people and those with other health problems who may not be able to handle a standard transplant and the side effects. The donor may be a relative or someone who is not related to you.Ī mini-transplant means that lower doses of chemotherapy and radiation are given before an allogeneic transplant. The second transplant is usually done between several weeks and 6 months after the first.Īllogeneic transplants use stem cells from someone else. Your stem cells for both transplants are usually collected before the first course of chemotherapy. Before each one, you are given high-dose chemotherapy. The type of transplant is based on who gives the stem cells.Īutologous transplants use stem cells from your own bone marrow or blood.Ī double autologous (tandem) transplant means that you receive 2 autologous transplants. a high-dose therapy with stem cell rescue.a hematopoietic stem cell transplant (HSCT).a peripheral blood stem cell transplant (PBSCT) – when the stem cells are taken from the blood. ![]() a bone marrow transplant – when the stem cells are taken from the bone marrow.If you receive stem cells from your identical twin, this is called a syngeneic transplant. In an autologous stem cell transplant, you provide your own stem cells. In an allogeneic stem cell transplant, stem cells are removed from another person (a donor) and given to you (the recipient). There are 2 major types of stem cell transplant – allogeneic and autologous. ![]() Stem cells are the most basic cells in the bone marrow, and they develop into different types of blood cells. The bone marrow’s main job is to make blood cells that flow through the body. It is used when stem cells or bone marrow have been damaged or destroyed by disease, including some types of cancer, or by high doses of chemotherapy or radiation therapy used to treat cancer.īone marrow is the soft, spongy tissue inside your large bones. A stem cell transplant replaces stem cells. ![]()
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